千空たちは、重病の村の巫女・ルリを救うため、万能薬・サルファ剤の作成を試みます。最も入手困難な材料である硫酸を求め、命がけの冒険に挑みます。一方、村では長の座をかけた武術大会『御前試合』が迫り――。科学と勇気が交錯する、緊迫の冒険が再び幕を開けます！

Imagine waking to a world where every last human has been mysteriously turned to stone...One fateful day, all of humanity turned to stone. Many millennia later, Taiju frees himself from the petrification and finds himself surrounded by statues. The situation looks grim-until he runs into his science-loving friend Senku! Together they plan to restart civilization with the power of science!Senku and friends make their way through the scientific road map that'll lead them to the Ruri's cure! Next up, a death-defying quest to obtain one of the deadliest substances on Earth-sulfuric acid! Meanwhile, the Grand Bout Martial Arts Tournament approaches, and the prize is a big one-the chief's throne!